 | Jacquelyn Gervay-Hague Professor Email: gervay@chem.ucdavis.edu Phone:(530) 754-9577 Fax:(530) 754-6915 Associate Editor, Journal of Organic Chemistry Email: joc@chem.ucdavis.edu Phone: (530) 752-0104 Fax: (530) 754-6915 2001-present Professor, Department of Chemistry, University of California, Davis 2000-2001 On-Site Consultant, Roche Bioscience, Palo Alto, CA (sabbatical) 1998-2000 Associate Professor, Department of Chemistry, The University of Arizona 1992-1998 Assistant Professor, Department of Chemistry, The University of Arizona 1990-1992 NIH Post-Doctoral Fellow, Department of Chemistry, Yale University, Professor Samuel J. Danishefsky 1990 Ph.D., UCLA, Organic Chemistry Publications | Patents | Dissertations | Distinguished Appointments and Awards More Info Group Page |
| Principal Research Interests |  |
The Gervay-Hague research group has established an Internationally recognized program in the area of carbohydrate chemistry directed toward the design and synthesis of chemotherapeutics targeting HIV infection and cancer. Although the disease states differ, our method of lead discovery has consistently involved understanding disease processes at a molecular level so that rational drug design can be implemented. This approach has led to studies at the interface of chemistry, biology, and virology. Our work is characterized by a total approach to drug design and synthesis that utilizes a wide variety of experimental tools available to chemists and biologists. | |
| Representative Publications Mechanistic Studies on the Stereoselective Formation of beta-Mannosides from Mannosyl Iodides Using alpha-Deuterium Kinetic Isotope Effects. M.H. El-Badri, D. Willenbring, D.J. Tantillo, and J. Gervay-Hague. J. Org. Chem., 2007, 72, 4663-4672. Efficient, One-Pot Synthesis of Biologically Active alpha-Linked Glycolipids. W. Du, S.S. Kulkarni, and J. Gervay-Hague. Chem. Commun., 2007, 23, 2336-2338. Direct Inactivation of Human Immunodeficiency Virus Type 1 by a Novel Small-Molecule Entry Inhibitor, DCM205. Y.T. Duong, D.C. Meadows, I.K. Srivastava, J. Gervay-Hague, and T.W. North. Antimicrob. Agent Chemother., 2007, 51, 1780-1786. Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates. K.D. McReynolds, and J. Gervay-Hague. Chem. Rev., 2007, 107,1533-1552. Construction of di-scFv Through a Trivalent Alkyne-Azide 1,3-Dipolar Cycloaddition. A. Natarajan, W. Du, C. Xiong, G.L. DeNardo, S.J. DeNardo and J. Gervay-Hague. Chem. Commun., 2007, 695-697. Ring Substituent Effects on Biological Activity of Vinyl Sulfones as Inhibitors of HIV-1. D.C. Meadows, and J. Gervay-Hague. Bioorg. Med. Chem., 2007, 15, 1127-1137. Efficient Synthesis of a C-Analogue of the Immunogenic Bacterial Glycolipid BbGl2. S.S. Kulkarni, and J. Gervay-Hague. Org. Lett., 2006, 8, 5765-5768. Vinyl Sulfones: Synthetic Preparations and Medicinal Chemistry Applications. D.C. Meadows, and J. Gervay-Hague. Med. Chem. Rev., 2006, 26, 793-814. Correlation of Biological Activity with Active Site Binding Modes of Geminal Disulfone HIV-1 Integrase Inhibitors. D.C. Meadows, D.J. Tantillo, and J. Gervay-Hague. ChemMedChem, 2006, 1, 959-964. Current Developments in HIV Chemotherapy. D.C. Meadows and J. Gervay-Hague. ChemMedChem, 2006, 1, 16-29. Polyvalent Interactions of HIV-gp120 Protein and Nanostructures of Carbohydrate Ligands. J.-J. Yu, B. Nolting, Y.H. Tan, X. Li, J. Gervay-Hague, and G.-y. Liu. NanoBiotechnology, 2005, 1,201-210. Quantitative Measurements of Recombinant HIV Surface Glycoprotein Gp120 Binding to Glycosphingolipids Expressed in Planar Supported Lipid Bilayers. J.C. Conboy, K.D. McReynolds, J. Gervay-Hague, and S.S. Saavedra. J. Am. Chem. Soc., 2002, 124, 968-977. Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy. J.C. Conboy, K. D. McReynolds, J. Gervay-Hague, and S.S. Saavedra. Angew. Chem. Int. Engl. Ed., 2000, 39, 2882-2884. | |