 | Carlito B. Lebrilla Professor Email: lebrilla@chem.ucdavis.edu Phone:(530) 752-6364 B.S., University of California, Irvine, 1981. Ph.D., University of California, Berkeley, 1985. Alexander von Humboldt postdoctoral Fellow, Technical University, Berlin, 1985-86. NATO-NSF Postdoctoral Fellow, Technical University, Berlin, 1986-87. UC President's Fellow, UC Irvine, 1988-89. Appointed to faculty, UC Davis, 1989-. Group Page |
| Principal Research Interests |  |
The focus of the group is in the development of analytical tools in two areas - nutrition and diseases. We are developing mass spectrometry based tools for the discovery of markers for cancer including ovarian, breast, and prostate. Our approach is to examine the post-translational modification of proteins particularly in the forms of glycosylation. We are pioneering the glycomics approach for the early diagnosis of cancer and developing the infrastruct! ure in terms of analytical tools and bioinformatics for glycan based disease marker discovery. We are also deconstructing the components of mammalian milk to determine what in milk makes it the perfect food for the infant. Milk has evolved with the infant to provide the perfect food. Milk not only contains nourishment but has components that are antibiotic, antiviral, and anticancer. Research in our laboratory has provided methods to examine milk and discover new bioactive components. The research group has a well-equipped mass spectrometry laboratory with state-of-the art separations methods. | |
| Representative Publications Fragmentation of Singly-Protonated Peptides via Combination of Infrared and Collisional Activation Dissociation, Dodds, E.D.; Hagerman, P.J.; Lebrilla, C.B. Anal. Chem. 2006, 78, 8506-8511. A new computer program (GlycoX) to determine simultaneous the glycosylation sites and oligosaccharde heterogeneity of glycoproteins. An, HJ; Tillinghast, JS; Woodruff, DL; Rocke, DM; Lebrilla, CB J. Proteome Res, 2006, 5, 2800-2808. A strategy for annotating the human milk glycome: towards understanding the role of oligosaccharides in health and diseases Niñonuevo, MR; Park, Y; Yin, H; Zhang, J; Ward, RE; Clowers, BH; German, JB; Freeman, SL; Killeen, K; Grimm, R; Lebrilla, CB J. Ag. Food Chem, 2006, 54, 7471-7480. Interrogation of N-linked oligosaccharides using infrared multi-photon dissociation in FT-ICR mass spectrometry, Lancaster, K.; An, HJ,; Li, BS,; Lebrilla, CB Anal. Chem., 2006, 78, 4990-4997. Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer, An. H.J.; Miyamoto, S.; Lancaster, K.S.; Kirmiz, C.; Li, B.; Lam, K.S.; Leiserowitz, G.S.; Lebrilla, C.B. J. Proteome Res., 2006, 5, 1626-1635. Automatic determination of O-glycan structure from fragmentation spectra, Goldberg, D.; Bern, M.; Li, B.S.; Lebrilla, C.B. J. Proteome Res. 2006, 5, 1429-1434. In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri, Ward, R.E.; Ninonuevo, M.; Mills, D.A.; Lebrilla, C.B.; German, J.B. Applied Env. Microbiology, 2006, 72, 4497-4499. Enhanced Peptide Mass Fingerprinting Through High Mass Accuracy: Exclusion of Non-Peptide Signals Based on Residual Mass, J. Proteome Res. 2006, 5, 1195-1203. | |