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Gang-yu Liu
Professor

Email: liu@chem.ucdavis.edu
Phone:(530) 754-9678
Fax:(530) 754-8557

B.S., Peking (Beijing) University, P. R. China, 1985.
M.A., Princeton University, 1987.
Ph.D., Princeton University, 1992.
CGP (Chemistry Graduate Program) Fellowship, Princeton University, 1986-1987.
Harold W. Dodds Honorific Fellowship, Princeton University, 1990-1991.
Miller Research Fellowship, University of California, Berkeley, 1992-1994.
Assistant Professor, Wayne State University, 1994-1999.
Camille and Henry Dreyfus New Faculty Award, 1994-1999.
Arnold and Mabel Beckman Young Investigator Award, 1996-1998.
Associate Professor with tenure, Wayne State University, 1999-2001.
Outstanding Scholarly Achievements Award, Wayne State University, 2000.
Career Development Chair Award, Wayne State University, 2000-2001.
Associate Professor with tenure, UC Davis, 2001-2005
Professor, UC Davis, 2005-
AAAS Fellow, 2007

NEAT ORU Spectral Imaging Facility

Editorial Office, Journal of Physical Chemistry

10 + 10 Alliance

Group Page
Principal Research Interests
Nanoscience and nanoengineering, bioanalytical chemistry, polyvalent biochemical interactions
Liu’s overall research objective focuses on the development of nanotechnology and its applications to bioanalytical chemistry. One important aspect of the research is the design and engineering nanostructures which position bioreceptors and chemical reaction sites on surfaces with high precision. The exquisite precision attainable by the nanolithographic methods that we have developed allows complex multivalent interactions typical of biorecognition to be controlled, by varying the separation and local environment of the binding sites. Current projects include: (1) development of state-of-the-art imaging tools for high-resolution imaging of ligands, DNA, proteins and cells; (2) advanced methodologies for productions of arrays of nanostructures; (3) single-cell imaging and mechanics; (4) using nanostructures of antibodies produced to investigate hypersensitivity reaction or allergy; (5) using nanostructures of ligands for study of the initial HIV infection of human T-cells; and (6) using nanostructures of ligands for the invetigation of cancer cell signaling.
Representative Publications

“Precise Positioning of Nanoparticles on Surfaces Using Scanning Probe Lithography” Garno, J. C.; Yang, Y.; Amro, N. A.; Cruchon-Dupeyrat, S.; Chen, S.; Liu, G. Y. Nano Letters 2003, 3, 389-395.

“Structures of Annealed Decanethiol SAMs on Gold: an UHV-STM Study” Qian, Y.; Yang, G. H.; Jung, T.; Liu, G. Y. Langmuir 2003, 19, 6056-6065.

“New Insights for Self-Assembled Monolayers of Organothiols Revealed by Scanning Tunneling Microscopy” Yang, G.; Liu, G. Y. J. Phys. Chem. Feature Article, 2003, 107, 8746-8759.

“Synthesis of gold glyconanoparticles and biological evaluation of recombinant Gp120 interactions” Nolting, B.; Yu, J. J.; Liu, G. Y.; Cho, S. J.; Kauzlarich, S.; Gervay-Hague, J. Langmuir 2003, 19, 6465-6473.

“Scanning probe lithography of self-assembled monolayers” Yang, G.; Amro, N. A.; Liu, G.-Y. Proc. SPIE 2003, 5220, 52-65.

“Molecular Level Approach to Inhibit Degradations of Alkanethiol Self-assembled Monolayers in Aqueous Media” Yang, G.; Amro, N. A.; Starkewolfe, Z. B.; Liu, G. Y. Langmuir 2003, 20, 3995-4003.

“Hybridization with Nanostructures of Single-Stranded DNA” Liu, M.; Liu, G. Y. Langmuir 2005, 21, 1972-1978.

“Single Electron Tunneling and Manipulation of Nanoparticles on Surfaces at Room Temperature” Yang, G.; Tan, L.; Yang, Y.; Chen, S.; Liu, G. Y. Surf. Sci. 2005, 589, 129-138.

“Probing Local Structure and Mechanical Response of Using Force Modulation and Nanofabrication” Price, W. J.; Kuo, P. K.; Lee, T. R.; Colorado R.; Ying, Z. C.; Liu, G. Y. Langmuir 2005, 21, 8422-8428.

“Polyvalent Interactions of HIV-gp120 Protein and Nanostructures of Carbohydrate Ligands” Yu, J.; Nolting, B.; Tan, Y. H.; Li, X.; Gervay-Hague, J.; Liu, G. Y. Nanobiotechnology 2006, 1, 201-210.

“Measuring the Size Dependence of Young’s Modulus Using Force Modulation Atomic Force Microscopy” Price, W. J.; Leigh, S. A.; Hsu, S. M.; Patten, T. E.; Liu, G. Y. J. Phys. Chem. 2006, 110, 1382-1388.

“A Simple Miniaturization Protocol to Produce Multi-component Micro- and Nano-structures” Ouyang, Z.; Tan, L.; Liu, M.; Judge, O. S.; Zhang, X.; Li, H.; Hu, J.; Patten, T. E.; Liu, G. Y. SMALL 2006, 7, 884-887 (cover).

“Cell Mechanics Using Atomic Force Microscopy Based Single Cell Compression” Lulevich, V.; Zink, T.; Chen, H.; Liu, F.; Liu, G. Y. Langmuir 2006, 22(19), 8151-8155 (cover).

“A Nanoengineering Approach to Regulate the Lateral Heterogeneity of Self-Assembled Monolayers” Yu, J.; Tan, Y. H.; Li, X.; Kuo, P. K.; Liu, G. Y. J. Am. Chem. Soc. 2006, 128(35), 11574-11581.

“High-Efficiency Stepwise Contraction and Adsorption Nanolithography” Tan, L.; Ouyang, Z.; Liu, M.; Ell, J.; Hu, J.; Patten, T. E.; Liu, G.-Y. J. Phys. Chem. B 2006, 110(46), 23315-23320.

“Significance of Local Density of States in the Scanning Tunneling Microscopy Imaging of Alkanethiol Self-assembled Monolayers” Riposan, A.; Liu, G.-Y. J. Phys. Chem. B 2006, 110(47), 23926-23937.

“Structural characterization of aldehyde–terminated self-assembled monolayers” Riposan, A.; Li, Y.; Tan, Y.H.; Galli, G.; Liu, G.-Y. J. Phys. Chem. B 2007, 111; 12727-12739.