Angelique Louie’s research is driven by the belief that imaging technologies offer unique testing grounds for probing the cellular and molecular basis of biological events. Her work employ a highly interdisciplinary approach to solve research problems, an amalgam of her fields of training, with the unifying theme being the applications of imaging techniques and the design of probes to characterize molecular phenomena. Specific interests are in the major health problems of retinal degeneration, cardiovascular disease and tumor formation. The unifying theme of this research is the application of imaging techniques and the design of probes to characterize molecular phenomena in diseased versus normal states. Much of the work involves the application of multiple imaging modalities. By using modalities in combination, one can exploit the strengths of each to maximize the information obtained by imaging. But the use of more than one imaging modality requires specialized probes with multiple modes of signal enhancement. Therefore, a primary component of her research is the development of novel imaging agents for molecular imaging, where molecular imaging is defined as the in vivo visualization of specific molecules or molecular function.