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Jared T. Shaw
Assistant Professor

Email: shaw@chem.ucdavis.edu
Phone:(530) 752-9979

University of California, Irvine, Ph.D.
Harvard University, Postdoctoral Fellow.
Broad Institute of Harvard and MIT, Institute Fellow.
Appointed to faculty, July 2007.
Amgen Research Award, 2005.
NIH Postdoctoral Fellowship, 1999-2001.
E. K. C. Lee Award for Excellence in Graduate Studies and Research, 1998.
ACS Division of Organic Chemistry Graduate Fellowship, 1997.
Department of Education/GAANN Fellowship, 1994-1996.
Group Page
Principal Research Interests
Our research is focused on the development of new reactions and the stereoselective synthesis of natural products and other biologically active molecules. We recently developed a novel four component reaction (4CR) that is being applied to the assembly of several complex polycyclic alkaloids. We are also synthesizing several natural products that target bacteria resistant to current antibiotics.
Representative Publications

High-Throughput Methods of Chemical Synthesis Applied to the Preparation of Inhibitors of Protein-Protein Interactions. A. K. Franz, J. T. Shaw, Y. Tang. Protein Surface Recognition: Approaches for Drug Discovery (Wiley-Interscience), 2007, in press.

N-Benzyl-3-sulfonamidopyrrolidines as Novel Inhibitors of Cell Division in E. coli. S. Mukherjee, C. A. Robinson, A. G. Howe,T. Mazor, P. A. Wood, S. Urgaonkar, A. M. Hebert, D. RayChaudhuri, J. T. Shaw, Bioorg. Med. Chem. Lett., 2007, 6651-6655.

Diastereoselective Synthesis of &gamma -Lactams by a One-pot, Four-component Reaction. J. Wei and J. T. Shaw, Org. Lett., 2007, 4077-4080.

Synthesis of a Diverse Library of Lactam Carboxamides Leading to the Discovery of an Inhibitor of HoxA13 Transcription. P. Y. Ng, Y. Tang, W. M. Knosp, H. S. Stadler, and J. T. Shaw, Angew. Chem. Int. Ed., 2007, 5352-5355.

A Structurally Diverse Library of Polycyclic Lactams resulting from Systematic Placement of Proximal Functional Groups. J. M. Mitchell and J. T. Shaw, Angew. Chem. Int. Ed. 2006, 45, 1722-1726.

Synthesis of Antimicrobial Natural Products Targeting FtsZ: (+/-)-Dichamanetin and (+/-)-2’’’-Hydroxy-5’’-benzylisouvarinol-B. S. Urgaonkar, H. S. La Pierre, I. Meir, H. Lund, D. RayChaudhuri, and J. T. Shaw, Org. Lett. 2005, 7, 5609-5612.