 | Annaliese K. Franz Assistant Professor Email: franz@chem.ucdavis.edu Phone:(530) 752-9820 University of California, Irvine, Ph.D. Harvard University, Postdoc Appointed to faculty, July 2007 NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow, 2002-2005 Abbott Laboratories Graduate Research Fellow, 2000 3M Nontenured Faculty Award, 2009 NSF CAREER Award, 2009 Group Page |
| Principal Research Interests |  |
Research in the Franz group combines organic synthesis, catalyst development, and chemical biology. We are working to develop new reactions and catalysts for the efficient synthesis of bioactive and therapeutically-relevant molecules. In addition to developing new transformations for the synthesis of complex small molecules, we are interested in the synthetic challenge of developing new reactions for protein modification and bioconjugation. An integral part of our research is to investigate the mechanism and molecular interactions that dictate the reactivity and selectivity of these synthetic transformations. | |
| Representative Publications A. K. Franz. The Synthesis of Biologically Active Organosilicon Small Molecules. Curr. Opin. Drug Disc. Dev. 2007, 10, 654–671.
A. K. Franz, P. D. Dreyfuss, and S. L. Schreiber. Synthesis and Cellular Profiling of Diverse Organosilicon Small Molecules. J. Am. Chem. Soc. 2007, 129, 1020–1021 T. G. Driver, A. K. Franz, and K. A. Woerpel. Diastereoseletive Silacyclopropanations of Functionalized Chiral Alkenes. J. Am. Chem. Soc. 2002, 124, 6524–6525. A. K. Franz, and K. A. Woerpel. ZnBr2-Catalyzed Insertions of Carbonyl Compounds into Silacyclopropanes: Regiochemical Reversal Dependent on Metal Salt. Angew. Chem. Int. Ed. 2000, 39, 4295–4299. A. K. Franz, and K. A. Woerpel. Development of Reactions of Silacyclopropanes as New Methods for Stereoselective Organic Synthesis. Acc. Chem. Res. 2000, 33, 813–820. A. K. Franz, and K. A. Woerpel. Stereospecific and Regioselective Reactions of Silacyclopropanes with Carbonyl Compounds Catalyzed by Copper Salts: Evidence for a Transmetalation Mechanism J. Am. Chem. Soc. 1999, 121, 949–957. | |