Claude
F. Meares
|
Professor |
Phone: (530) 752-0936 |
|
Department of Chemistry |
or 752-3360 |
|
University of California |
Fax:
(530)752-8938 |
|
One Shields Avenue |
E-mail: cfmeares@ucdavis.edu |
|
Davis, California 95616-5295 |
www-chem.ucdavis.edu/people/meares.html |
Born: September 25, 1946, in Wilmington, North Carolina.
Education
B. S. in Chemistry
University
of North Carolina, Chapel Hill,
North
Carolina, 1968 (awarded with highest honors)
Ph. D. in Chemistry
Stanford
University, Stanford, California, 1972.
Employment
Chemistry Faculty, University of California, Davis
Assistant
Professor 1972-1978
Associate
Professor 1978-1982
Professor 1982-present
Dept.
Chair 1997-2000
Honors
Association
for Laboratory Automation Achievement Award, 2002
Immunomedics
Science Award, 1998
Fellow,
American Association for the Advancement of Science, 1994
Distinguished Scientist Award, 1994, Society of Nuclear
Medicine, Western Region
Visiting
Committee, Brookhaven National Laboratory Medical Department, 1993-1997
Editor-In-Chief, Bioconjugate Chemistry, 1989-
(American Chemical Society)
Member, Board of Editors, Inorganic Chemistry,
1989- (American Chemical Society)
NIH MERIT award, 1991 (CA 16861)
Member, Metallobiochemistry Study Section, NIH Division of
Research Grants, 1982-1986
NIH Research Career Development Award, 1979-1984
von Hevesy
Prize for Nuclear Medicine, 1974
NSF
Graduate Fellow, 1968-1972, Stanford University
Venable
Medal, 1968, University of North Carolina
Phi Beta
Kappa, 1967, University of North Carolina
Research Interests
Bioconjugate chemistry, molecular biology, application of
chemical techniques to biological and biomedical problems, mapping
protein-protein and protein-nucleic acid interactions, bifunctional chelating
agents, engineered antibodies.
Publications
1. Reuben D. Rieke, Claude F. Meares, and Loretta I. Rieke. Ring Strain Effects on Spin Densities — 1. Ring Strain Effects on Spin Densities in Substituted Naphthalene Radical Anions. Tetrahedron Letters 51, 5275-5278 (1968).
2. Claude F. Meares, Robert G. Bryant, John D. Baldeschwieler, David A. Shirley. Study of Carbonic Anhydrase Using Perturbed Angular Correlations of Gamma Radiation. Proceedings of the National Academy of Sciences (USA) 64, 1155-1161 (1969).
3. Reuben D. Rieke, Steve E. Bales, Phillip M. Hudnall, and Claude F. Meares. Benzocyclobutene Radical Anion. Journal of American Chemical Society 92, 1418-1420 (1970).
4. Reuben D. Rieke, Steve E. Bales, Phillip M. Hudnall, and Claude F. Meares. Benzocyclobutene Radical Anion. Journal of the American Chemical Society 93, 697-703 (1971).
5. Alan G. Marshall, and Claude F. Meares. Effect of Slow Rotational Diffusion on Angular Correlations. Journal of Chemical Physics 56, 1226-1229 (1972).
6. Claude F. Meares and David G. Westmoreland. Study of Biological Macromolecules using Perturbed Angular Correlations of Gamma Radiation. Cold Spring Harbor Symposia on Quantitative Biology 36, 511-516 (1971).
7. Alan G. Marshall, Lawrence G. Werbelow, and Claude F. Meares. Effect of Molecular Shape and Flexibility on Gamma-ray Directional Correlations. Journal of Chemical Physics 57, 364-370 (1972).
8. David A. Goodwin, Claude F. Meares, and Chung H. Song. Study of 111 Indium-Labeled Compounds in Mice, using Perturbed Angular Correlations of Gamma Radiations. Radiology 105, 699-702 (1972).
9. Claude F. Meares, Michael W. Sundberg, and John D. Baldeschwieler. Perturbed Angular Correlation Study of a Haptenic Molecule., Proceedings of the National Academy of Sciences (USA) 69, 3718-3722 (1972).
10. Michael W. Sundberg, Claude F. Meares, David A. Goodwin, and Carol I. Diamanti. Chelating Agents for the Binding of Metal Ions to Macromolecules. Nature 250, 587-588 (1974).
11. Reuben D. Rieke, Stephen E. Bales, Claude F. Meares, Loretta I. Rieke, and Charles M. Milliren. Ring Strain Effects. IV. Electron Spin Resonance Study of the Radical Anions of a Series of Strained Naphthalene Hydrocarbons. Journal of Organic Chemistry 39, 2276-2281 (1974).
12. Michael W. Sundberg, Claude F. Meares, David A. Goodwin, and Carol I. Diamanti. Selective Binding of Metal Ions to Macromolecules Using Bifunctional Analogs of EDTA. Journal of Medicinal Chemistry 17, 1304-1307 (1974).
13. David A. Goodwin, Michael W. Sundberg, Carol I. Diamanti, and Claude F. Meares. Indium-111 Radiopharmaceuticals in Cancer Localization. Tumor Diagnosis (Radiologic and other Biophysical Methods) , 57-88 (1975).
14. David A. Goodwin, Claude F. Meares, Carol I. Diamanti, and Michael W. Sundberg. Bifunctional Chelates for Radio-pharmaceutical Labeling. Nuclear-Medizin 14, 365-373 (1975).
15. David A. Goodwin, Michael W. Sundberg, Carol I. Diamanti, and Claude F. Meares. 111 In-labeled Radiopharmaceuticals and Their Clinical Use. Radiopharmaceuticals (ISBN 0-88416-041-6) , 80-100 (1975).
16. David A. Goodwin and Claude F. Meares. Radiolabeled Antitumor Agents. Seminars in Nuclear Medicine 6, 389-396 (1976).
17. Claude F. Meares, David A. Goodwin, Charles S-H. Leung, Amal Y. Girgis, David J. Silvester, Adrian D. Nunn, and Peter J. Lavender. Covalent Attachment of Metal Chelates to Proteins: The Stability in Vivo and in Vitro of the Conjugate of Albumin with a Chelate of 111-Indium. Proceedings of the National Academy of Sciences (USA) 73, 3803-3806 (1976).
18. Charles S-H. Leung, and Claude F. Meares. Attachment of Fluorescent Metal Chelates to Macromolecules Using "Bifunctional" Chelating Agents. Biochemical and Biophysical Research Communications 75, 149-155 (1977).
19. Charles S-H. Leung, B. A. Swartz, and Claude F. Meares. Analysis by Perturbed Angular Correlations of the Binding of Indium-111 to Radiopharmaceutical Chelates. Radiochemical and Radioanalytical Letters 29, 151-157 (1977).
20. Shirley M. Halling, F. J. Sanchez-Anzaldo, Ryuji Fukuda, Roy H. Doi, and Claude F. Meares. Zinc is Associated with the Beta Subunit of DNA-dependent RNA Polymerase of Bacillus subtilis. Biochemistry 16, 2880-2884 (1977).
21. David A. Goodwin, Claude F. Meares, Carol I. Diamanti, and Jerrold T. Bushberg. Biological Properties of Molecules Labeled with Metal Ions Using Bifunctional Chelates. Medical Radionuclide Imaging (IAEA Symposium, Los Angeles, California, October 1976, IAEA-SM-210/91) 2, 61-69 (1978).
22. Terry B. Rogers, Robert E. Feeney, and Claude F. Meares. Interaction of Anions with Iron•transferrin•chelate Complexes. Journal of Biological Chemistry 252, 8108-8112 (1977).
23. Claude F. Meares, and Joseph E. Ledbetter. Energy Transfer Between Terbium and Iron Bound to Transferrin: Reinvestigation of the Distance Between Metal-Binding Sites. Biochemistry 16, 5178-5180 (1977).
24. Lyle S. Rice, and Claude F. Meares. Subunit Contacts of the Rifamycin Binding Site of RNA Polymerase (B. Subtilis). Biochemical and Biophysical Research Communications 80, 26-32 (1978).
25. David A. Goodwin, Jerrold T. Bushberg, Paul W. Doherty, Martin J. Lipton, Frances K. Conley, Carol I. Diamanti, and Claude F. Meares. Indium-III-labeled Autologous Platelets for Location of Vascular Thrombi in Humans. Journal of Nuclear Medicine 19, 626-634 (1978).
26. Paul W. Doherty, Jerrold T. Bushberg, Martin J. Lipton, Claude F. Meares, and David A. Goodwin. The Use of Indium-111-Labeled Leukocytes for Abscess Detection. Clinical Nuclear Medicine 3, 108-110 (1978).
27. Charles S-H. Leung, Claude F. Meares, and David A. Goodwin. The Attachment of Metal-Chelating Groups to Proteins: Tagging of Albumin by Diazonium Coupling and Use of the Products as Radiopharmaceuticals. International Journal of Applied Radiation and Isotopes 29, 687-692 (1978).
28. Simon M. Yeh, and Claude F. Meares. Amphiphilic Spectroscopic Probes Utilizing Metal Chelates. Experientia 35, 715-716 (1979).
29. Leslie H. DeRiemer, Claude. F. Meares, David A. Goodwin, and Carol I. Diamanti. BLEDTA: Tumor Localization by a Bleomycin Analog Containing a Metal-chelating Group. Journal of Medicinal Chemistry 22, 1019-1023 (1979).
30. Simon M. Yeh, David G. Sherman, and Claude F. Meares. A New Route to "Bifunctional" Chelating Agents: Conversion of Amino Acids to Analogs of Ethylenedinitrilotetraacetic Acid. Analytical Biochemistry 100, 152-159 (1979).
31. Simon M. Yeh, Claude F. Meares, and David A. Goodwin. Decomposition Rates of Radiopharmaceutical Indium Chelates in Serum. Journal of Radioanalytical Chemistry 53, 327-336 (1979).
32. David A. Goodwin, Claude F. Meares, Leslie H. DeRiemer, Carol I. Diamanti and Richard L. Goode. In-III BLEDTA: A Conjugate of Bleomycin with a Bifunctional Chelating Agent for Tumor Localization. Radiopharmaceuticals II (Proceedings of the Second International Symposium on Radiopharmaceuticals) , 275-284 (1979).
33. Claude F. Meares, Leslie H. DeRiemer, and David A. Goodwin. Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine. Bleomycin: Chemical, Biochemical,and Biological Aspects (Proceedings of Joint US/Japan Conference on Bleomycin, Honolulu, HI, 1978) , 307-321 (1980).
34. David A. Goodwin, Claude F. Meares, Carol I. Diamanti, and Jerrold T. Bushberg. Biological Properties of Molecules Labeled with Metal Ions using Bifunctional Chelates. Nuklearmedizin und Biokybernetik , 623-627 (1978).
35. Martin J. Lipton, Paul W. Doherty, David A. Goodwin, Jerrold T. Bushberg, Robert Prager, and Claude F. Meares. Evaluation of Catheter Thrombogenicity in Vivo with Indium-labeled Platelets. Radiology 135, 191-194 (1980).
36. David A. Goodwin and Claude F. Meares. Bifunctional Chelates for Radiopharmaceutical Labeling. In Radiopharmaceuticals: Structure-Activity Relationships , 281-306 (1980).
37. Simon M. Yeh, and Claude F. Meares. Characterization of Transferrin Metal-binding Sites by Diffusion-enhanced Energy Transfer. Biochemistry 19, 5057-5062 (1980).
38. Claude F. Meares, Simon M. Yeh, and Lyle S. Rice. Diffusion-enhanced Lanthanide Energy Transfer Studies of Protein Prosthetic Groups. Biophysical Journal (Biophysical Discussions: Proteins and Nucleoproteins Structure, Dynamics, and Assembly, Airlie, Virginia, May 18-21, 1980) 32, 228-229 (1980).
39. Claude F. Meares, and Lyle S. Rice. Diffusion-enhanced Energy Transfer Shows Accessibility of Ribonucleic Acid Polymerase Inhibitor Binding Sites. Biochemistry 20, 610-617 (1981).
40. Leslie H. DeRiemer, and Claude F. Meares. Synthesis of Mono- and Dinucleotide Photoaffinity Probes of Ribonucleic Acid Polymerase. Biochemistry 20, 1606-1612 (1981).
41. Leslie H. DeRiemer and Claude F. Meares. Early Steps in the Path of Nascent Ribonucleic Acid Across the Surface of Ribonucleic Acid Polymerase, Determined by Photoaffinity Labeling. Biochemistry 20, 1612-1617 (1981).
42. Claude F. Meares and Simon M. Yeh. Exchange Interaction Contribution to Energy Transfer Between Ions in the Rapid-diffusion Limit. Journal of the American Chemical Society 103, 1607-1609 (1981).
43. Patricia O'Hara, Simon M. Yeh, Claude F. Meares, and Richard Bersohn. Distance Between Metal-binding Sites in Transferrin: Energy Transfer from Bound Terbium(III) to Iron(III) or Manganese(III). Biochemistry 20, 4704-4708 (1981).
44. Leslie H. DeRiemer, Claude F. Meares, David A. Goodwin, and Carol I. Diamanti. BLEDTA II: Synthesis of a New Tumor-visualizing Derivative of Cobalt(III)-bleomycin. Journal of Labelled Compounds and Radiopharmaceuticals 18, 1517-1534 (1981).
45. David A. Goodwin, Claude F. Meares, Leslie H. DeRiemer, Carol I. Diamanti, Richard L. Goode, John E. Baumert, David J. Sartoris, Robert L. Lantieri, and H. Daniel Fawcett. Clinical Studies with In-111 BLEDTA, A Tumor-Imaging Conjugate of Bleomycin with Bifunctional Chelating Agent. Journal of Nuclear Medicine 22, 787-792 (1981).
46. Claude F. Meares, Leslie H. DeRiemer, Charles S.-H. Leung, Simon M. Yeh, Michiko Miura, David G. Sherman, David A. Goodwin, and Carol I. Diamanti. Properties in Vivo of Chelate-tagged Proteins and Polypeptides. Advances in Chemistry Series (Modification of Proteins) , 369-387 (1982).
47. Chien-Hsing Chang, Claude F. Meares, and David A. Goodwin. Bifunctional Chelating Agents: Linking Radiometals to Biological Molecules. Applications of Nuclear and Radiochemistry , 103-114 (1982).
48. Lubert Stryer, David D. Thomas, and Claude F. Meares. Diffusion-enhanced Fluorescence Energy Transfer. Annual Review of Biophysics and Bioengineering 11, 203-222 (1982).
49. Claude F. Meares Diffusion-enhanced Energy Transfer Studies of the Metal-binding Sites of Human Transferrin. The Biochemistry and Physiology of Iron (Proceedings of International Conference, Proteins Iron Storage Transp., 5th, Meeting Date 1981) , 19-25 (1982).
50. Richmond J. Baker, Carol I. Diamanti, David A. Goodwin, and Claude F. Meares. Technetium-99m Complexes of EDTA Analogs: Studies of the Radiochemistry and Biodistribution. International Journal of Nuclear Medicine and Biology 8, 159-169 (1981).
51. Lyle S. Rice and Claude F. Meares. Effects of Sigma Subunit and DNA Template on the Accessibility of Rifamycin Bound to RNA Polymerase. Biochemical and Biophysical Research Communications 105, 51-56 (1982).
52. Chien-Hsing Chang and Claude F. Meares. Light-induced Nicking of Deoxyribonucleic Acid by Cobalt(III) Bleomycins. Biochemistry 21, 6332-6334 (1982).
53. Chien-Hsing Chang, Jerry L. Dallas, and Claude F. Meares. Identification of a Key Structural Feature of Cobalt(III)-bleomycins: An Exogenous Ligand (e.g. Hydroperoxide) Bond to Cobalt. Biochemical and Biophysical Research Communications 110, 959-966 (1983).
54. Michelle M. Hanna and Claude F. Meares. Topography of Transcription: Path of the Leading End of Nascent RNA through the Escherichia Coli Transcription Complex. Proceedings of the National Academy of Sciences (USA) 80, 4238-4242 (1983).
55. Michelle M. Hanna and Claude F. Meares. Synthesis of a Cleavable Dinucleotide Photoaffinity Probe of Ribonucleic Acid Polymerase: Application to Trinucleotide Labeling of an Escherichia Coli Transcription Complex. Biochemistry 22, 3546-3551 (1983).
56. Michael H. Penner, R. Bryan Yamasaki, David T. Osuga, Donald R. Babin, Claude F. Meares, and Robert E. Feeney. Comparative Oxidations of Tyrosines and Methionines in Transferrins: Human Serum Transferrin, Human Lactotransferrin, and Chicken Ovotransferrin. Archives of Biochemistry and Biophysics 225, 740-747 (1983).
57. Theodore G. Wensel and Claude F. Meares. "Bifunctional" Chelating Agents for Binding Metal Ions to Proteins. Radioimmunoimaging and Radioimmunotherapy , 185-196 (1983).
58. Theodore G. Wensel and Claude F. Meares. Electrostatic Properties of Myoglobin Probed by Diffusion-enhanced Energy Transfer. Biochemistry 22, 6247-6254 (1983).
59. Robert E. Feeney, David T. Osuga, Claude F. Meares, Donald R. Babin, and Michael H. Penner. Studies on Iron-binding Sites of Transferrin by Chemical Modification. Structure and Function of Iron Storage Transport Proteins (Proceedings 6th International Conference) , 231-240 (1983).
60. Chien-Hsing Chang and Claude F. Meares. Cobalt-bleomycins and Deoxyribonucleic Acid: Sequence-dependent Interactions, Action Spectrum for Nicking, and Indifference to Oxygen. Biochemistry 23, 2268-2274 (1984).
61. Adnan Abusaleh and Claude F. Meares. Excitation and De-excitation Processes in Lanthanide Chelates Bearing Aromatic Sidechains. Photochemistry and Photobiology 39, 763-769 (1984).
62. David A. Goodwin, Claude F. Meares, Carol I. Diamanti, Michael J. McCall, Corazon Lai, Frank Torti, Maureen McTigue, and Brian Martin. Use of Specific Antibody for Rapid Clearance of Circulating Blood Background from Radiolabeled Tumor Imaging Proteins. European Journal of Nuclear Medicine 9, 209-215 (1984).
63. David J. Sartoris, David A. Goodwin, Claude F. Meares, Leslie H. DeRiemer, and Luis F. Fajardo. Pharmacokinetics of Indium-111-labeled BLEDTA in Man. Investigative Radiology 19, 221-227 (1984).
64. Claude F. Meares and Theodore G. Wensel. Metal Chelates as Probes of Biological Systems. Accounts of Chemical Research 17, 202-209 (1984).
65. Claude F. Meares and David A. Goodwin. Linking Radiometals to Proteins with Bifunctional Chelating Agents. Journal of Protein Chemistry 3, 215-228 (1984).
66. Sally J. DeNardo, John A. Jungerman, Gerald L. DeNardo, Manuel C. Lagunas-Solar, William C. Cole, and Claude F. Meares. The Choice of Radionuclides for Radioimmunotherapy. Department of Energy (DOE) Symposium Series, 56 (Dev. Role Short-Lived Radionuclides Nuclear Med. Pract.) , 401-414 (1985).
67. Claude F. Meares, Michael J. McCall, Dayton T. Reardan, David A. Goodwin, Carol I. Diamanti, and Maureen McTigue. Conjugation of Antibodies with Bifunctional Chelating Agents: Isothiocyanate and Bromoacetamide Reagents, Methods of Analysis, and Subsequent Addition of Metal Ions Analytical Biochemistry 142, 68-78 (1984).
68. David A. Goodwin, Claude F. Meares, Michael J. McCall, Michael K. Haseman, Maureen McTigue, Carol I. Diamanti, and Warak Chaovapong. Chelate Conjugates of Monoclonal Antibodies for Imaging Lymphoid Structures in the Mouse. Journal of Nuclear Medicine 26, 493-502 (1985).
69. Michael H. Penner,David T. Osuga, Claude F. Meares, and Robert E. Feeney. Interaction of Oxidized Chicken Ovotransferrin with Chicken Embryo Red Blood Cells. Biochimica et Biophysica Acta 827, 389-395 (1985).
70. Theodore G. Wensel, Chien-Hsing Chang, and Claude F. Meares. Diffusion-enhanced Lanthanide Energy-transfer Study of DNA-bound Cobalt(III) Bleomycins: Comparisons of Accessibility and Electrostatic Potential with DNA Complexes of Ethidium and Acridine Orange. Biochemistry 24, 3060-3069 (1985).
71. Dayton T. Reardan, Claude F. Meares, David A. Goodwin, Maureen McTigue, Gary S. David, Mary R. Stone, Julia P. Leung, Richard M. Bartholomew, and James M. Frincke. Antibodies Against Metal Chelates. Nature 316, 265-268 (1985).
72. Min K. Moi, Claude F. Meares, Michael J. McCall, William C. Cole, and Sally J. DeNardo. Copper Chelates as Probes of Biological Systems: Stable Copper Complexes with a Macrocyclic Bifunctional Chelating Agent. Analytical Biochemistry 148, 249-253 (1985).
73. Ramaswamy Subramanian and Claude F. Meares. Photo-Induced Nicking of Deoxyribonucleic Acid by Ruthenium(II)-Bleomycin in the Presence of Air. Biochemical and Biophysical Research Communications 133, 1145-1151 (1985).
74. David A. Goodwin and Claude F. Meares. Indium-111 Labeled Cells: New Approaches and Radiation Dosimetry. Radiolabeled Cellular Blood Elements , 343-362 (1985).
75. David A. Goodwin, S. I. Smith, Claude F. Meares, Gary S. David, Maureen McTigue, R. A. Finston. Chelate Chase of Radiopharmaceuticals Reversibly Bound to Monoclonal Antibodies Improves Dosimetry. Fourth International Radiopharmaceutical Dosimetry Symposium, Proceedings (CONF-851113—DE86010102, 11/5-8/85) , 477-491 (1986).
76. Theodore G. Wensel, Claude F. Meares, Vojko Vlachy, and James B. Matthew. Distribution of Ions Around DNA, Probed by Energy Transfer. Proceedings of the National Academy of Sciences (USA) 83, 3267-3271 (1986).
77. Susan L. Bernhard and Claude F. Meares. The Sigma Subunit of RNA Polymerase Contacts the Leading Ends of Transcripts 9-13 Bases Long on the Lambda PR Promoter but not on T7 A1. Biochemistry 25, 5914-5919 (1986).
78. Susan L. Bernhard and Claude F. Meares. Accessibility of the Leading End of Ribonucleic Acid in Transcription Complexes. Biochemistry 25, 6397-6404 (1986).
79. Ramaswamy Subramanian and Claude F. Meares. Photosensitization of Cobalt Bleomycin. Journal of the American Chemical Society 108, 6427-6429 (1986).
80. Claude F. Meares Chelating Agents for the Binding of Metal Ions to Antibodies. Nuclear Medicine and Biology 13, 311-318 (1986).
81. David A. Goodwin, Claude F. Meares, Maureen McTigue, and Gary S. David. Monoclonal Antibody Hapten Radiopharmaceutical Delivery. Nuclear Medicine Communications 7, 569-580 (1986).
82. William C. Cole, Sally J. DeNardo, Claude F. Meares, Michael J. McCall, Gerald L. DeNardo, Alan L. Epstein, Harold A. O'Brien, and Min K. Moi. Serum Stability of 67Cu Chelates: Comparison with 111In and 57Co. Nuclear Medicine and Biology 13, 363-368 (1986).
83. David A. Goodwin, Claude F. Meares, G. F. David, Maureen McTigue, Michael J. McCall, James M. Frincke, Mary R. Stone, Richard M. Bartholomew, and Julia P. Leung. Monoclonal Antibodies as Reversible Equilibrium Carriers of Radiopharmaceuticals. Nuclear Medicine and Biology 13, 383-391 (1986).
84. David A. Goodwin, Claude F. Meares, Maureen McTigue, Michael J. McCall, and Warak Chaovapong. Metal Decomposition Rates of 111In-DTPA and EDTA Conjugates of Monoclonal Antibodies in Vivo. Nuclear Medicine Communications 7, 831-838 (1986).
85. Michael K. Haseman, David A. Goodwin, Claude F. Meares, Mark S. Kaminski, Theodore G. Wensel, Michael J. McCall, and Ronald Levy. Metabolizable Indium-111 Chelate Conjugated Anti-Idiotype Monoclonal Antibody for Radioimmunodetection of Lymphoma in Mice. European Journal of Nuclear Medicine 12, 455-460 (1986).
86. Blaine Bartholomew, Michael E. Dahmus, and Claude F. Meares. RNA Contacts Subunits IIo and IIc in HeLa RNA Polymerase II Transcription Complexes. Journal of Biological Chemistry 261, 14226-14231 (1986).
87. Claude F. Meares. Attaching Metal Ions to Antibodies. Protein Tailoring for Food and Medical Uses (Chapter 13). , 339-452 (1986).
88. Claude F. Meares. Physiological Barriers to Chelate-tagged Monoclonals? Trends in Biotechnology 5, 10 (1987).
89. William C. Cole, Sally J. DeNardo, Claude F. Meares, Michael J. McCall, Gerald L. DeNardo, Alan L. Epstein, and Harold A. O'Brien, Min K. Moi. Comparative Serum Stability of Radiochelates for Antibody Radiopharmaceuticals. Journal of Nuclear Medicine 28, 83-90 (1987).
90. Michael H. Penner, David T. Osuga, Claude F. Meares, and Robert E. Feeney. The Interaction of Anions with Native and Phenylglyoxal-Modified Human Serum Transferrin. Archives of Biochemistry and Biophysics 252, 7-14 (1987).
91. Min K. Moi, Michael Yanuck, Shrikant V. Deshpande, Håkon Hope, Sally J. DeNardo, and Claude F. Meares. X-ray Crystal Structure of a Macrocyclic Copper Chelate Stable Enough for use in Living Systems: Copper(II) Dihydrogen 6-(p-Nitrobenzyl)-1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetate. Inorganic Chemistry 26, 3458-3463 (1987).
92. Claude F. Meares, Michael J. McCall, Shrikant V. Deshpande, Sally J. DeNardo and David A. Goodwin. Chelate Radiochemistry: Cleavable Linkers Lead to Altered Levels of Radioactivity in the Liver. International Journal of Cancer (Supplement 2) , 99-102 (1988).
93. David A. Goodwin, Claude F. Meares, Michael J. McCall, Maureen McTigue, and Warak Chaovapong. Pre-targeted Immunoscintigraphy of Murine Tumors with Indium-111-Labeled Bifunctional Haptens. Journal of Nuclear Medicine 29, 226-234 (1988).
94. Shrikant V. Deshpande, Sally J. DeNardo, Claude F. Meares, Michael J. McCall, Gregory P. Adams, Min K. Moi, and Gerald L. DeNardo. Copper-67-Labeled Monoclonal Antibody Lym-1, A Potential Radiopharmaceutical for Cancer Therapy: Labeling and Biodistribution in RAJI Tumored Mice. Journal of Nuclear Medicine 29, 217-225 (1988).
95. Thomas M. Stackhouse and Claude F. Meares. Photoaffinity Labeling of Escherichia coli RNA Polymerase/Poly [d(A-T)] Transcription Complexes by Nascent RNA. Biochemistry 27, 3038-3045 (1988).
96. Min K. Moi, Claude F. Meares, and Sally J. DeNardo. The Peptide Way to Macrocyclic Bifunctional Chelating Agents: Synthesis of 2-(p-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,-N',N",N'''-tetraacetic Acid and Study of Its Yttrium (III) Complex. Journal of the American Chemical Society 110, 6266-6267 (1988).
97. Claude F. Meares. Use of Bifunctional Chelating Agents for Radiolabeling Antibodies Radiolabeled Monoclonal Antibodies for Imaging and Therapy, NATO Advanced Study Institute on Antibodies (Italy, 7/86) , 229-238 (1988).
98. Sally J. DeNardo, Gerald L. DeNardo, Shrikant V. Deshpande, Gregory P. Adams, Daniel J. Macey, Stanley L. Mills, Alan L. Epstein, and Claude F. Meares. A Design of a Radiolabeled Monoclonal Antibody for Radioimmunodiagnosis and Radioimmunotherapy. Radiolabeled Monoclonal Antibodies for Imaging and Therapy , 111-122 (1988).
99. Gregory P. Adams, Sally J. DeNardo, Shrikant V. Deshpande, Gerald L. DeNardo, Claude F. Meares, Michael J. McCall, and Alan L. Epstein. Effect of Mass of IN-111 Benzyl-EDTA Monoclonal Antibody on Hepatic Uptake and Processing in Mice. Cancer Research 49, 1707-1711 (1987).
100. Stanley L. Mills, Sally J. DeNardo, Gerald L. DeNardo, Shrikant V. Deshpande, Michael J. McCall, Claude F. Meares, and Alan L. Epstein. Radiopharmaceutical Preparation of a Monoclonal Antibody, Lym-1, and its F(ab')2 Fragment for Imaging Lymphoma with In-111. Journal of Labelled Compounds and Radiopharmaceuticals 27, 377-386 (1988).
101. Theodore G. Wensel and Claude F. Meares. Study of Biological Macromolecules by Diffusion-Enhanced Lanthanide Energy Transfer. Journal of the Less-Common Metals 149, 143-160 (1988).
102. Thomas M. Stackhouse and Claude F. Meares. Quantitative Photoaffinity Labeling of Escherichia coli RNA Polymerase Transcription Complexes by Nascent RNA Photochemical Probes in Biochemistry , 261-275 (1988).
103. Isao Saito, Takashi Morii, Hiroshi Sugiyama, Teruo Matsuura, Claude F. Meares, and Sidney M. Hecht. Photoinduced DNA Strand Scission by Cobalt Bleomycin Green Complex. Journal of the American Chemical Society 111, 2307-2308 (1989).
104. Utpala Ramesh and Claude F. Meares. Footprint of the Sigma Protein. Biochemical and Biophysical Research Communications 160, 121-125 (1989).
105. Thomas M. Stackhouse, Alice P. Telesnitsky, and Claude F. Meares. The Release of the Sigma Subunit from Escherichia coli RNA Polymerase Transcription Complexes is Dependent on the Promoter Sequence Biochemistry 28, 7781-7788 (1989).
106. Shrikant V. Deshpande, Sally J. DeNardo, Claude F. Meares, Michael J. McCall, Gregory P. Adams, and Gerald L. DeNardo. Effect of Different Linkages Between Chelates and Monoclonal Antibodies on Levels of Radioactivity in the Liver. Nuclear Medicine Biology 16, 587-597 (1989).
107. Shrikant V. Deshpande, Ramaswamy Subramanian, Michael J. McCall, Sally J. DeNardo, Gerald L. DeNardo, and Claude F. Meares. Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium from Benzyl-EDTA Chelate in Vivo The Journal of Nuclear Medicine 31, 218-224 (1990).
108. Blaine Bartholomew, Claude F. Meares, and Michael E. Dahmus. Photoaffinity Labeling of RNA Polymerase III Transcription Complexes by Nascent RNA Journal of Biological Chemistry 265, 3731-3737 (1990).
109. Min K. Moi, Sally J. DeNardo, and Claude F. Meares. Stable Bifunctional Chelates of Metals Used in Radiotherapy. Cancer Research (Supplement) 50, 789-793 (1989).
110. Tariq M. Rana and Claude F. Meares. Specific Cleavage of a Protein by an Attached Iron Chelate. Journal of the American Chemical Society 112, 2457-2458 (1990).
111. Sally J. DeNardo, Shrikant V. Deshpande, Min K. Moi, Gerald P. Adams, Michael J. McCall, Gerald L. DeNardo, and Claude F. Meares. Today and Tomorrow: Radiochemistry for Radioimmunotherapy of Breast Cancer. Frontiers of Radiation Therapy and Oncology 24, 142-150 (1990).
112. Shrikant V. Deshpande, Sally J. DeNardo, David L. Kukis, Michael J. McCall, Gerald L. DeNardo, and Claude F. Meares. Yttrium-90 Labeled Monoclonal Antibody for Therapy: Labeling by a new Macrocyclic Bifunctional Chelating Agent. Journal of Nuclear Medicine 31, 473-479 (1990).
113. Michael J. McCall, Habibe Diril, and Claude F. Meares. Simplified Method for Conjugating Macrocyclic Bifunctional Chelating Agents to Antibodies via 2-Iminothiolane. Bioconjugate Chemistry 1, 222-226 (1990).
114. Ramaswamy Subramanian and Claude F. Meares. Bifunctional Chelating Agents for Radiometal-labeled Monoclonal Antibodies. Cancer Imaging with Radiolabeled Antibodies 9, 183-199 (1989).
115. Claude F. Meares, Min K. Moi, Habibe Diril, David L. Kukis, Michael J. McCall, Shrikant V. Deshpande, Sally J. DeNardo, Deborah Snook, and Agamemnon A. Epenetos. Macrocyclic Chelates of Radiometals for Diagnosis and Therapy. British Journal of Cancer (Supplement) 62, 21-26 (1990).
116. Carla J. Mathias, Michael J. Welch, Mark A. Green, Habibe Diril, Claude F. Meares, Robert J. Gropler, and Steven R. Bergmann. In Vivo Comparison of Copper Blood Pool Agents: Potential Radiopharmaceuticals for Use with Copper-62. The Journal of Nuclear Medicine 32, 475-480 (1991).
117. Arthur A. Wellman and Claude F. Meares. Sequences of the Lym-1 Antibody Heavy and Light Chain Variable Regions. Nucleic Acids Research 18, 5281 (1990).
118. Scott H. Northrup, Theodore G. Wensel, Claude F. Meares, John J. Wendoloski, and James B. Matthew. Electrostatic Field Around Cytochrome c: Theory and Energy Transfer Experiment. Proceedings of the National Academy of Sciences (USA) 87, 9503-9507 (1990).
119. Tariq M. Rana and Claude F. Meares. N-terminal Modification of Immunoglobulin Polypeptide Chains Tagged with Isothiocyanato Chelates. Bioconjugate Chemistry 1, 357-362 (1990).
120. Tariq M. Rana and Claude F. Meares. Iron Chelate-Mediated Proteolysis: Protein Structure Dependence. Journal of the American Chemical Society 113, 1859-1861 (1991).
121. Arthur Wellman and Claude F. Meares Footprint of the Sigma Protein: A Re-Examination Biochemical and Biophysical Research Communications 177, 140-144 (1991).
122. Claude F. Meares. Mapping the Path of a Growing Ribonucleic Acid Molecule. Accounts of Chemical Research 24, 183-190 (1991).
123. Gerald DeNardo, Sally DeNardo, David Kukis, Habibe Diril, Cathy Suey and Claude Meares Strategies for Enhancement of Radioimmunotherapy Int. J. Radiat. Appl. Instrum. Part B, Nucl. Med. Biol. 18, 633-640 (1991).
124. Claude F. Meares, Habibe Diril, David Kukis, Mike McCall, Tariq Rana, Arthur Wellman, Sally J. DeNardo and Gerald L. DeNardo Radiochemistry of Antibodies: Some Recent Advances Antibody, Immunoconjugates, and Radiopharmaceuticals 88, 389-398 (1991).
125. Tariq M. Rana and Claude F. Meares Transfer of Oxygen from an Artificial Protease to Peptide Carbon During Proteolysis Proceedings of the National Academy of Sciences USA 88, 10578-10582 (1991).
126. Gerald L. DeNardo, Sally J. DeNardo, Claude F. Meares, Dave Kukis, Habibe Diril, Michael J. McCall, Greg P. Adams, Leonard F. Mausner, David C. Moody and Shrikant V. Deshpande. Pharmacokinetics of Copper-67 Conjugated Lym-1, a Potential Therapeutic Radioimmunoconjugate, in Mice and in Patients with Lymphoma Antibody, Immunoconjugates, and Radiopharmaceuticals 4, 777-785 (1991).
127. Christos Kosmas, Deborah Snook, Calvin S. Gooden, Nigel S. Courtenay-Luck, Michael J. McCall, Claude F. Meares, and Agamemnon A. Epenetos. Development of Humoral Immune Responses against a Macrocyclic Chelating Agent (DOTA) in Cancer Patients Receiving Radioimmunoconjugates for Imaging and Therapy. Cancer Research 52, 904-911 (1992).
128. V. Hird, M. Verhoeyen, R.A. Badley, D. Price, D. Snook, C. Kosmas, C. Gooden, A. Bamias, C. Meares, J.P. Lavender, & A.A. Epenetos. Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. Br. J. Cancer 64, 911-914 (1991).
129. Martin Studer and Claude F. Meares. Synthesis of Novel 1,4,7-Triazacyclononane-N,N',N"-triacetic Acid Derivatives Suitable for Protein Labeling. Bioconjugate Chemistry 3, 337-341 (1992).
130. Carolyn J. Anderson, Judith M. Connett, Sally W. Schwarz, Pamela A. Rocque, Li Wu Guo, Gordon W. Philpott, Kurt R. Zinn, Claude F. Meares and Michael J. Welch. Copper-64-Labeled Antibodies for PET Imaging. The Journal of Nuclear Medicine 33, 1685-1691 (1992).
131. Martin Studer and Claude F. Meares. A Convenient and Flexible Approach for Introducing Linkers on Bifunctional Chelating Agents. Bioconjugate Chemistry 3, 420-423 (1992).
132. Martin Studer, Linda A. Kroger, Sally J. DeNardo, David L. Kukis, and Claude F. Meares. Influence of a Peptide Linker on Biodistribution and Metabolism of Antibody Conjugated Benzyl-EDTAs. Comparison of Enzymatic Digestion in Vitro and in Vivo. Bioconjugate Chemistry 3, 424-429 (1992).
133. David A Goodwin, Claude F. Meares, Maureen McTigue, Warak Chaovapong, Carol I. Diamanti, Charles H. Ransone, and Michael J. McCall. Pretargeted Immunoscintigraphy: Effect of Hapten Valency on Murine Tumor Uptake. Journal of Nuclear medicine, 33, 2006-2013 (1992).
134. Oliver Renn and Claude F. Meares. Large-Scale Synthesis of the Bifunctional Chelating Agent 2-(P-Nitrobenzyl)-1,4,7,10-Tetraazacyclododecane-N,N',N',N'''-Tetraacetic Acid, and the Determination of Its Enantiomeric Purity by Chiral Chromatography. Bioconjugate Chemistry 3, 563-569 (1992).
135. Min Li and Claude F. Meares. Synthesis, Metal Chelate Stability Studies, And Enzyme Digestion Of A Peptide-Linked DOTA Derivative And Its Corresponding Radiolabeled Immunoconjugates. Bioconjugate Chemistry 4, 275-283 (1993).
136. Xue-Bao Shi, Paul H. Gumerlock, Arthur A. Wellman, Claude F. Meares, Gerald L. DeNardo, Frederick J. Meyers, and Sally J. DeNardo. Rapid PCR Construction of a Gene Containing Lym-1 Antibody Variable Regions. PCR Methods and Applications 3, 46-53 (1993).
137. V. Hird, A. Maraveyas, D. Snook, B. Dhokia, W.P. Soutter, C.F. Meares, J.S.W. Stewart, P. Mason, H.E. Lambert, and A.A. Epenetos. Adjuvant Therapy Of Ovarian Cancer With Radioactive Monoclonal Antibody. British Journal Of Cancer 68, 403-406 (1993).
138. David L. Kukis, Min Li, and Claude F. Meares. The Selectivity of Antibody-Chelate Conjugates for Binding Copper in the Presence of Competing Metals. Inorganic Chemistry 32, 3981-3982 (1993).
139. Kosmas, C.; Snook, D. E.; Gooden, C. S.; Courtenay-Luck, N. S.; McCall, M. J.; Meares, C. F.; Epenetos, A. A. Immunogenicity of a macrocyclic chelating agent (DOTA) in patients receiving radiolabeled antibody-guided imaging and therapy. Monoclonal Antibodies 2, 39-51. Edited by: Epenetos, Agamemnon A. Chapman and Hall: London, UK. (1993).
140. Naoto Watanabe, David A. Goodwin, Claude F. Meares, Maureen McTigue, Warak Chaovapong, Charles McK. Ransone, and Oliver Renn. Immunogenicity In Rabbits And Mice Of An Antibody-Chelate Conjugate: Comparison Of (S) And (R) Macrocyclic Enantiomers, And An Acyclic Chelating Agent. Cancer Research 54, 1049-1054 (1994).
141. David L. Kukis, Habibe Diril, Douglas P. Greiner, Sally J. DeNardo, Gerald L. DeNardo, Qansy A. Salako, and Claude F. Meares. A Comparative Study of Copper-67 Radiolabeling and Kinetic Stabilities of Antibody-Macrocyclic Chelate Conjugates. Cancer Supplement 73, 779-786 (1994).
142. Gerald L. DeNardo, Linda A. Kroger, Sally J. DeNardo, Laird A. Miers, Qansy A. Salako, David L. Kukis, Irwin Fand, Suey Shen, Oliver Renn, and Claude F. Meares. Comparative Toxicity Studies of Yttrium-90 MX-DTPA and 2-IT BAD Conjugated Monoclonal Antibody (BrE-3). Cancer Supplement 73, 1012-1022 (1994).
143. Min Li, Claude F. Meares, Gao-Ren Zhong, Laird Miers, Cheng-Yi Xiong, and Sally J. DeNardo. Labeling Monoclonal Antibodies with 90Yttrium- and 111Indium-DOTA Chelates: a Simple and Efficient Method. Bioconjugate Chemistry 5, 101-104 (1994).
144. Meares, Claude F.; Editor. Perspectives in Bioconjugate Chemistry. (Book) (ACS: Washington, D. C.), 209 pp. (1993).
145. Goodwin DA; Meares CF; Watanabe N; McTigue M; Chaovapong W; Ransone CM; Renn O; Greiner DP; Kukis DL; Kronenberger SI. Pharmacokinetics Of Pretargeted Monoclonal Antibody 2D12.5 And Y-88-Janus-2-(p-Nitrobenzyl)-1,4,7,10-Tetraazacyclododecanetetraacetic Acid (DOTA) In Balb/c Mice With KHJJ Mouse Adenocarcinoma - A Model For Y-90 Radioimmunotherapy. Cancer Research 54, 5937-5946 (1994).
146. Maraveyas A; Snook D; Hird V; Kosmas C; Meares CF; Lambert HE; Epenetos AA. Pharmacokinetics And Toxicity Of An Yttrium-90-CITC-DTPA-HMFG1 Radioimmunoconjugate For Intraperitoneal Radioimmunotherapy Of Ovarian Cancer. Cancer, 73, 1067-1075 (1994).
147. Heilek GM; Marusak R; Meares CF; Noller HF. Directed Hydroxyl Radical Probing Of 16S rRNA Using Fe(II) Tethered To Ribosomal Protein S4. Proceedings Of The National Academy Of Sciences Of The United States Of America, 92, 1113-1116 (1995).
148. Anderson CJ; Schwarz SW; Connett JM; Cutler PD; Guo LW; Germain CJ; Philpott GW; Zinn KR; Greiner DP; Meares CF; Welch MJ. Preparation, Biodistribution and Dosimetry of Copper-64-Labeled Anti-Colorectal Carcinoma Monoclonal Antibody Fragments 1A3-F(ab')2. Journal of Nuclear Medicine, 36(5), 850-858 (1995).
149. DeNardo SJ; Zhong G-R; Salako Q; Li M; DeNardo GL; Meares CF. Pharmacokinetics of Chimeric L6 Conjugated to Indium-111- and Yttrium-90-DOTA-Peptide in Tumor-Bearing Mice. Journal of Nuclear Medicine, 36(5), 829-836 (1995).
150. Moran JK; Greiner DP; Meares CF. Improved Synthesis of 6-[p-(Bromoacetamido)Benzyl]-1,4,8,11-tetraazacyclotetradecane-N,N',N",N'"-tetraacetic Acid and Development of a Thin-Layer Assay for Thiol-Reactive Bifunctional Chelating Agents. Bioconjugate Chemistry, 6, 296-301 (1995).
151. Kukis DL; DeNardo GL; DeNardo SJ; Mirick GR; Miers LA; Greiner DP; Meares CF. Effects of the Extent of Chelate Substitution on the Immunoreactivity and Biodistribution of 2IT-BAT-LYM-1 Immunoconjugates. Cancer Research, 55(4), 878-884 (1995).
152. Moran JK; Olmstead MM; Meares CF. An Aminobenzyldioxocyclam Nickel(II) Complex. Acta Crystallographica Section C, C51, 621-623 (1995).
153. Ghaim, JB; Greiner, DP; Meares, CF; Gennis, RB. Proximity Mapping the Surface of a Membrane Protein Using an Artificial Protease: Demonstration that the Quinone-Binding Domain of Subunit I is Near the N-Terminal Region of Subunit II of Cytochrome bd. Biochemistry, 34, 11311-11315 (1995).
154. Philpott, GW, Schwarz, SW, Anderson, CJ, Dehdashti, F, Connett, JM, Zinn, KR, Meares, CF, Cutler, PD, Welch, MJ, and Siegel, BA. RadioimmunoPET: Detection of Colorectal Carcinoma with Positron-Emitting Copper-64-Labeled Monoclonal Antibody. Journal of Nuclear Medicine, 36, 1818-1824 (1995).
155. Li M; Meares CF; Salako Q; Kukis DL; Zhong GR; Miers L; DeNardo SJ. Prelabeling of Chimeric Monoclonal Antibody L6 with 90Yttrium- And 111Indium-1,4,7,10-Tetraazacyclododecane-N,N',N",N"'-Tetraacetic Acid (DOTA) Chelates for Radioimmunodiagnosis and Therapy. Cancer Research, 55(23 Suppl):5726s-5728s (1995).
156. Greiner, DP; Hughes, KA; Gunasekera, AH; Meares, CF. Binding of the Sigma-70 Protein to the Core Subunits of Escherichia coli RNA Polymerase, Studied by Iron-EDTA Protein Footprinting. Proceedings of the National Academy of Sciences USA 93, 71-75 (1996).
157. Denardo GL; Mirick GR; Kroger LA; Odonnell RT; Meares CF; Denardo SJ. Antibody Responses to Macrocycles in Lymphoma. Journal of Nuclear Medicine, 37, 451-456 (1996).
158. Renn O; Goodwin DA; Studer M; Moran JK; Jacques V; Meares CF. New Approaches To Delivering Metal-Labeled Antibodies To Tumors - Synthesis And Characterization Of New Biotinyl Chelate Conjugates For Pre-Targeted Diagnosis And Therapy. Journal of Controlled Release 39, 239-249 (1996).
159. Greiner DP; Hughes KA; Meares CF. Radiolytic Protein Surface Mapping. Biochemical and Biophysical Research Communications, 225, 1006-1008 (1996).
160. Rose LM; Gunasekera AH; Denardo SJ; Denardo GL; Meares CF. Lymphoma Selective Antibody Lym-1 Recognizes A Discontinuous Epitope On The Light Chain Of HLA-DR10. Cancer Immunology Immunotherapy, 43: 26-30 (1996).
161. DeNardo, GL; Kukis, DL; Shen, S; Mausner, LF; Meares, CF; Srivastava, SC; Miers, LA; DeNardo, SJ. Efficacy and Toxicity of 67Cu-2IT-BAT-Lym-1 Radioimmunoconjugate in Mice Implanted with Human Burkitt’s Lymphoma (Raji). Clinical Cancer Research, 3: 71-79 (1997).
162. Douglas P. Greiner, Reiko Miyake, Justin K. Moran, A. Daniel Jones, Tomofumi Negishi, Akira Ishihama, and Claude F. Meares. Synthesis of the Protein Cutting Reagent Iron (S)-1-(p-bromoacetamidobenzyl)ethylenediaminetetraacetate (Fe-BABE), and Conjugation to Cysteine Sidechains. Bioconjugate Chemistry 8, 44-48 (1997).
163. Murakami, K; Kimura, M; Owens, JT; Meares, CF; Ishihama, A. The two alpha subunits of Escherichia coli RNA polymerase are asymmetrically arranged and contact different halves of the DNA upstream element. Proceedings of the National Academy of Sciences USA 94, 1709-1714 (1997).
164. Chinol, M; Paganelli, G; Sudati, F; Meares, C; Fazio, F. Biodistribution in tumour-bearing mice of two Y-90-labelled biotins using three-step tumour targeting. Nuclear Medicine Communications, 18, 176-182 (1997).
165. Sally J. DeNardo, David L. Kukis, Linda A. Kroger, Robert T. O'Donnell, Kathleen R. Lamborn, Laird A. Miers, David G. DeNardo, Claude F. Meares, and Gerald L. DeNardo. Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: Efficacy and toxicity in breast cancer xenografts. Proceedings of the National Academy of Sciences USA 94, 4000-4004 (1997).
166. DeNardo, SJ; Richman, CM; Goldstein, DS; Shen, S; Salako, Q; Kukis, DL; Meares, CF; Yuan, A; Welborn, JL; DeNardo, GL. Yttrium-90/indium-111-DOTA-peptide-chimeric L6: Pharmacokinetics, dosimetry and initial results in patients with incurable breast cancer. Anticancer Research, 17 #3b:1735-1744 (1997).
167. Rakesh Mogul and Claude F. Meares. Mapping an antibody binding site by nuclear decay. Journal of the American Chemical Society 119, 7169-7170 (1997).
168. Katsuhiko Murakami, Jeffrey T. Owens, Tamara A. Belyaeva, Claude F. Meares, Stephen J.W. Busby, and Akira Ishihama. Positioning of two alpha subunit carboxy-terminal domains of RNA polymerase at promoters by two transcription factors. Proceedings of the National Academy of Sciences USA 94, 11274-11278 (1997).
169. David A. Goodwin and Claude F. Meares. Pretargeting - General principles. Cancer 80, supps:2675-2680 (1997).
170. Nicholson, S; Gooden, CSR; Hird, V; Maraveyas, A; Mason, P; Lambert, HE; Meares, CF; Epenetos, AA. Radioimmunotherapy after chemotherapy compared to chemotherapy alone in the treatment of advanced ovarian cancer: A matched analysis. Oncology Reports 5, 223-226 (1998).
171. Miyake, R; Murakami, K; Owens, JT; Greiner, DP; Ozoline, ON; Ishihama, A; Meares, CF. Dimeric association of Escherichia coli RNA polymerase a subunits, studied by cleavage of single-cysteine alpha subunits conjugated to iron-(S)-1-[p-(bromoacetamido)benzyl]–ethylenediaminetetraacetate. Biochemistry 37, 1344-1349 (1998).
172. Owens, JT; Miyake, R; Murakami, K; Chmura, AJ; Fujita, N; Ishihama, A; Meares, CF. Mapping the sigma(70) subunit contact sites on Escherichia coli RNA polymerase with a sigma(70)-conjugated chemical protease. Proceedings of the National Academy of Sciences USA 95, 6021-6026 (1998).
173. Owens, JT; Chmura, AJ; Murakami, K; Fujita, N; Ishihama, A; Meares, CF. Mapping the promoter DNA sites proximal to conserved regions of sigma(70) in an Escherichia coli RNA polymerase-lacUV5 open promoter complex. Biochemistry 37, 7670-7675 (1998).
174. DeNardo, SJ; Kukis, DL; Miers, LA; Winthrop, MD; Kroger, LA; Salako, Q; Shen, S; Lamborn, KR; Gumerlock, PH; Meares, CF; DeNardo, GL. Yttrium-90-DOTA-peptide chimeric L6 radioimmunoconjugate: Efficacy and toxicity in mice bearing p53 mutant human breast cancer xenografts. Journal of Nuclear Medicine 39, 842-849 (1998).
175. Feng, X; Pak, RH; Kroger, LA; Moran, JK; DeNardo, DG; Meares, CF; DeNardo, GL; DeNardo, SJ. New anti-Cu-TETA and anti-Y-DOTA monoclonal antibodies for potential use in the pre-targeted delivery of radiopharmaceuticals to tumor. Hybridoma 17, 125-132 (1998).
176. James J. Peterson and Claude F. Meares. Cathepsin Substrates as Cleavable Peptide Linkers in Bioconjugates, Selected from a Fluorescence Quench Combinatorial Library. Bioconjugate Chemistry 9, 618-626 (1998).
177. David A. Goodwin, Claude F. Meares and Maureen Osen. Biological Properties of Biotin-Chelate Conjugates for Pretargeted Diagnosis and Therapy with the Avidin/Biotin System. Journal of Nuclear Medicine 39, 1813-1818 (1998).
178. Denardo, Gerald L.; Denardo, Sally J.; Kukis, David L.; O'Donnell, Robert T.; Shen, Sui; Goldstein, Desiree S.; Kroger, Linda A.; Salako, Qansy; Denardo, Diane A.; Mirick, Gary R.; Mausner, Leonard F.; Srivastava, Suresh C.; Meares, Claude F. Maximum tolerated dose of 67Cu-2IT-BAT-LYM-1 for fractionated radioimmunotherapy of non-hodgkin's lymphoma: A pilot study. Anticancer Res. 18(4B), 2779-2788 (1998).
179. DeNardo, Gerald L.; Kroger, Linda A.; Meares, Claude F.; Richman, Carol M.; Salako, Qansy; Shen, Sui; Lamborn, Kathleen R.; Peterson, James J.; Miers, Laird A.; Zhong, Gao Ren; DeNardo, Sally J. Comparison of 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-Peptide-ChL6, a Novel Immunoconjugate with Catabolizable Linker, to 2-Iminothiolane-2-(p-(Bromoacetamido)benzyl]-DOTA-ChL6 in Breast Cancer Xenografts. Clinical Cancer Research 4, 2483-2490 (1998).
180. Kukis, David L.; DeNardo, Sally J.; DeNardo, Gerald L.; O'Donnell, Robert T.; Meares, Claude F. Optimized Conditions for Chelation of Yttrium-90-DOTA Immunoconjugates. The Journal of Nuclear Medicine 39, 2105-2110 (1998).
181. Song, Kyung Bin; Won, Misun; Meares, Claude F. Expression of recombinant Lym-I single-chain Fv in Escherichia coli. Biotechnol. Appl. Biochem. 28, 163-167 (1998).
182. Paganelli, Giovanni; Magnani, Patrizia; Chinol, Marco; Sudati, Francesco; Zito, Felicia; Mangili, Francesca; Li, Min; Meares, Claude F.; Siccardi, Antonio G.; Fazio, Ferruccio. Pilot therapy trial of CEA positive tumours using a three-step pretargeting approach. Tumor Targeting 3, 96-104 (1998).
183. Bown, JA; Owens, JT; Meares, CF; Fujita, N; Ishihama, A; Busby, SJW; Minchin, SD. Organization of open complexes at Escherichia coli promoters - Location of promoter DNA sites close to region 2.5 of the sigma(70) subunit of RNA polymerase. Journal of Biological Chemistry, 274, 2263-2270 (1999).
184. DeNardo, Sally J.; DeNardo, Gerald L.; Kukis, David L.; Shen, Sui; Kroger, Linda A.; DeNardo, Diane A.; Goldstein, Desiree S.; Mirick, Gary R.; Salako, Qansy; Mausner, Leonard F.; Srivastava, Suresh C.; Meares, Claude F. 67Cu-2IT-BAT-Lym-1 Pharmacokinetics, Radiation Dosimetry, Toxicity and Tumor Regression in Patients with Lymphoma. The Journal of Nuclear Medicine 40, 302-310 (1999).
185. Peterson, James J.; Pak, Roger H.; Meares, Claude F. Total Solid-Phase Synthesis of 1,4,7,10-Tetraazacyclododecane-N,N' , N'' , N''' - tetraacetic Acid-Functionalized Peptides for Radioimmunotherapy . Bioconjugate Chemistry 10, 316-320 (1999).
186. DeNardo, GL; Kukis, DL; Shen, S; DeNardo, DA; Meares, CF; DeNardo, SJ. Cu-67-versus I-131-labeled Lym-1 antibody: Comparative pharmacokinetics and dosimetry in patients with non-Hodgkin's lymphoma. Clinical Cancer Research 5, 533-541 (1999).
187. Traviglia, SL; Datwyler, SA; Meares, CF. Mapping Protein-Protein Interactions with a Library of Tethered Cutting Reagents: The Binding Site of Sigma (70) on Escherichia coli RNA Polymerase. Biochemistry 38, 4259-4265 (1999).
188. Peterson, James J.; Meares, Claude F. Enzymatic Cleavage of Peptide-Linked Radiolabels from Immunoconjugates. Bioconjugate Chemistry; 10, 553-557 (1999).
189. Goodwin, DA, Meares, CF. Pretargeted peptide imaging and therapy. Cancer Biotherapy And Radiopharmaceuticals, 14, 145-152 (1999).
190. Colland, F, Fujita, N, Kotlarz, D, Bown, JA, Meares, CF, Ishihama, A, Kolb, A. Positioning of sigma(S), the stationary phase sigma factor, in Escherichia coli RNA polymerase-promoter open complexes. EMBO Journal, 18, 4049-4059 (1999).
191. Miyake, R, Owens, JT, Xu, DD, Jackson, WM, Meares, CF. Site-directed photocleavage for mapping protein architecture. Journal Of The American Chemical Society, 121, 7453-7454 (1999).
192. Traviglia, SL; Datwyler, SA; Yan, D; Ishihama, A; Meares, CF. Targeted Protein Footprinting: Where Different Transcription Factors Bind to RNA Polymerase. Biochemistry, 38, 15774-15778 (1999).
193. Rose, LM; Deng, CT; Scott, SL; Xiong, CY; Lamborn, KR, Gumerlock, PH; DeNardo, GL; Meares, CF. Critical Lym-1 binding residues on polymorphic HLA-DR molecules. Molecular Immunology, 36, 789-797 (1999).
194. Mirick, GR, O'Donnell, RT, DeNardo, SJ, Shen, S, Meares, CF, DeNardo, GL. Transfer of copper from a chelated Cu-67-antibody conjugate to ceruloplasmin in lymphoma patients. Nuclear Medicine and Biology, 26, 841-845 (1999).
195. DeNardo,GL, Meares, CF, et al. Radiation dosimetry for 90Y-2IT-BAD-Lym-1 extrapolated from pharmacokinetics using 111In-2IT-BAD-Lym-1 in patients with non-Hodgkin's lymphoma. Journal of Nuclear Medicine, 41, 952-958 (2000).
196. Bown, JA, Kolb, A, Meares, CF, Ishihama, A, Minchin SD, Busby SJW. Positioning of Region 4 of the Escherichia coli RNA Polymerase sigma 70 Subunit by a Transcription Activator. J. Bacteriol, 182, 2982-2984 (2000).
197. Corson, DT, Meares, CF. Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid. Bioconjugate Chemistry, 11, 292-299 (2000).
198. Alan R. Fritzberg and Claude F. Meares. Metallic Radionuclides for Radioimmunotherapy. In Radioimmunotherapy of Cancer, Abrams, PG and Fritzberg, AR eds, Chapter 3, pp. 57-79, Marcel Dekker, New York (2000).
199. Saul A. Datwyler and Claude F. Meares. Protein-protein interactions mapped by artificial proteases: where s factors bind to RNA polymerase. Trends in Biochemical Sciences, 25, 408-414 (2000).
200. B. W. Wessels and C. F. Meares. Physical and chemical properties of radionuclide therapy. Semin.Radiat.Oncol. 10 (2):115-122, 2000.
201. Lee, Jonghui; Owens, Jeffrey T.; Hwang, Ingyu; Meares, Claude; Kustu, Sydney. Phosphorylation-induced signal propagation in the response regulator NtrC. J. Bacteriol. (2000), 182(18), 5188-5195.
202. S. A. Datwyler and C. F. Meares. Artificial Iron-Dependent Proteases, in "Probing of Proteins by Metal Ions and Their Low-Molecular-Weight Complexes", Vol. 38 of Met. Ions Biol. Syst., A. Sigel and H. Sigel, eds., M. Dekker, New York, pp. 213-254 (2001).
203. John Voss, Jianhua Wu, Wayne L. Hubbell, Vincent Jacques, Claude F. Meares, and H. Ronald Kaback. Helix Packing in the Lactose Permease of Escherichia coli: Distances between Site-Directed Nitroxides and a Lanthanide. Biochemistry (2001), 40, 3184-3188.
204. Lubic SP, Goodwin DA, Meares CF, Song C, Osen M, Hays M. Biodistribution and dosimetry of pretargeted monoclonal antibody 2d12.5 and Y-janus-dota in balb/c mice with khjj mouse adenocarcinoma. J Nucl Med. 42(4):670-8 (2001).
205. Chmura, Albert J.; Orton, Molly S.; Meares, Claude F. Antibodies with infinite affinity. Proc. Natl. Acad. Sci. USA 98(15), 8480-8484 (2001).
206. Marr MT, Datwyler SA, Meares CF, Roberts JW. Inaugural Article: Restructuring of an RNA polymerase holoenzyme elongation complex by lambdoid phage Q proteins. Proc Natl Acad Sci USA. 98(16):8972-8 (2001).
207. DeNardo GL, DeNardo SJ, Kukis DL, O'Donnell RT, Shen S, Mirick GR, Meares CF. Metabolite production in patients with lymphoma after radiometal-labeled antibody administration. J Nucl Med 42(9):1324-1333 (2001).
208. David A. Goodwin and Claude F. Meares. Advances in pretargeting biotechnology. Biotechnology Advances 19: 435–450 (2001).
209. Chmura, AJ, Schmidt, BD, Corson, DT, Traviglia, ST, Meares, CF. Electrophilic chelating agents for binding of metal chelates to engineered antibodies. J. Controlled Release 78: 249-258 (2002).
210. Brian D. Schmidt and Claude F. Meares. Proteolytic DNA for Mapping Protein-DNA Interactions. Biochemistry 41, 4186-4192 (2002).
211. Corneillie TM, Whetstone PA, Fisher AJ, Meares CF. A rare earth-DOTA-binding antibody: Probe properties and binding affinity across the lanthanide series. Journal of the American Chemical Society 125 (12): 3436-3437 (2003).
212. Meares, Claude F.; Chmura, A. J.; Orton, Molly S.; Corneillie, Todd M.; Whetstone, Paul A. Molecular tools for targeted imaging and therapy of cancer. Journal of Molecular Recognition 16(5), 255-259 (2003).
213. Corneillie, Todd M.; Fisher, Andrew J.; Meares, Claude F. Crystal Structures of Two Complexes of the Rare-Earth-DOTA-Binding Antibody 2D12.5: Ligand Generality from a Chiral System. Journal of the American Chemical Society 125(49), 15039-15048 (2003).
214. Meares CF, Datwyler SA, Schmidt BD, Owens J, Ishihama A. Principles and methods of affinity cleavage in studying transcription. Methods Enzymol. 371:82-106 (2003).
215. Paul A. Whetstone, Nathaniel G. Butlin, Todd M. Corneillie, and Claude F. Meares. Element-Coded Affinity Tags for Peptides and Proteins. Bioconjugate Chemistry 15(1), 3-6 (2004).
216. Whetstone PA, Akizawa H, Meares CF. Evaluation of Cleavable (Tyr(3))-octreotate Derivatives for Longer Intracellular Probe Residence. Bioconjug Chem. 2004 May-Jun;15(3):647-57.
217. Corneillie TM, Whetstone PA, Lee KC, Wong JP, Meares CF. Converting weak binders into infinite binders. Bioconjugate Chem. 2004;15(6):1389-1391.
218. Corneillie TM, Lee KC, Whetstone PA, Wong JP, Meares CF. Irreversible Engineering of the Multielement-Binding Antibody 2D12.5 and Its Complementary Ligands. Bioconjugate Chem. 2004;15(6):1392-1402.
219. Richman CM, Denardo SJ, O'Donnell RT, Yuan A, Shen S, Goldstein DS, Tuscano JM, Wun T, Chew HK, Lara PN, Kukis DL, Natarajan A, Meares CF, Lamborn KR, DeNardo GL. High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium-111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody. Clin Cancer Res. 2005 Aug 15;11(16):5920-7.
220. Lee S, Young NL, Whetstone PA, Cheal SM, Benner WH, Lebrilla CB, Meares CF. Method to site-specifically identify and quantitate carbonyl end products of protein oxidation using oxidation-dependent element coded affinity tags (O-ECAT) and nanoliquid chromatography Fourier transform mass spectrometry. Journal of Proteome Research 2006; 5 (3): 539-547.
221. Corneillie TM, Whetstone PA, Meares CF. Irreversibly binding anti-metal chelate antibodies: Artificial receptors for pretargeting. J Inorg Biochem. 2006 May;100(5-6):882-90.
222. Butlin NG, Meares CF. Antibodies with infinite affinity: origins and applications. Acc Chem Res. 2006 Oct;39(10):780-7. (Cover Article)
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